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The use of antibiotics is not permitted in Switzerland; moreover, no other medication exists to combat European foul brood. Hives with symptoms must therefore be destroyed in order to limit the outbreak, and the contaminated material must be sanitised. Since prevention is the best cure, early detection is desirable. Numerous studies have been undertaken and documents have been created at the Swiss Bee Research Centre and elsewhere to draw the attention of beekeepers to these problems and inform them about the causes and the control measures to be implemented.

Merkblatt zur erkennung von Bienenbrutkrankheiten (German (PDF, 357 kB, 18.10.2017) and French (PDF, 226 kB, 02.02.2017))
M. Tschumi (2011)

Serum metabolites responding in a dose-dependent manner to the intake of a high-fat meal in normal weight healthy men are associated with obesity.

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Bütikofer U., Burnand D., Portmann R., Blaser C., Schwander F., Kopf-Bolanz K. A., Laederach K., Badertscher R., Walther B., Vergères G.

Serum metabolites responding in a dose-dependent manner to the intake of a high-fat meal in normal weight healthy men are associated with obesity.

Metabolites, 11, (6), 2021, 1-16.

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Riassunto:

Although the composition of the human blood metabolome is influenced both by the health status of the organism and its dietary behavior, the interaction between these two factors has been poorly characterized. This study makes use of a previously published randomized controlled crossover acute intervention to investigate whether the blood metabolome of 15 healthy normal weight (NW) and 17 obese (OB) men having ingested three doses (500, 1000, 1500 kcal) of a high-fat (HF) meal can be used to identify metabolites differentiating these two groups. Among the 1024 features showing a postprandial response, measured between 0 h and 6 h, in the NW group, 135 were dose-dependent. Among these 135 features, 52 had fasting values that were significantly different between NW and OB men, and, strikingly, they were all significantly higher in OB men. A subset of the 52 features was identified as amino acids (e.g., branched-chain amino acids) and amino acid derivatives. As the fasting concentration of most of these metabolites has already been associated with metabolic dysfunction, we propose that challenging normal weight healthy subjects with increasing caloric doses of test meals might allow for the identification of new fasting markers associated with obesity.

ISSN Online: 2218-1989
Digital Object Identifier (DOI): https://doi.org/10.3390/metabo11060392
ID pubblicazione (Codice web): 46616 Inviare via e-mail

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Serum metabolites responding in a dose-dependent manner to the intake of a high-fat meal in normal weight healthy men are associated with obesity.