Control

The use of antibiotics is not permitted in Switzerland; moreover, no other medication exists to combat European foul brood. Hives with symptoms must therefore be destroyed in order to limit the outbreak, and the contaminated material must be sanitised. Since prevention is the best cure, early detection is desirable. Numerous studies have been undertaken and documents have been created at the Swiss Bee Research Centre and elsewhere to draw the attention of beekeepers to these problems and inform them about the causes and the control measures to be implemented.

Merkblatt zur erkennung von Bienenbrutkrankheiten (German (PDF, 357 kB, 18.10.2017) and French (PDF, 226 kB, 02.02.2017))
M. Tschumi (2011)

Analysis of volatile short-chain fatty acids in the gas phase using secondary electrospray ionization high-resolution mass spectrometry.

Institutional Repository Agroscope

Wüthrich C., Fan Z., Vergères G., Wahl F., Zenobi R., Giannoukos S.

Analysis of volatile short-chain fatty acids in the gas phase using secondary electrospray ionization high-resolution mass spectrometry.

Analytical Methods, 15, (5), 2023, 553-561.

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Zusammenfassung:

Quantification of metabolites present within exhaled breath is a major challenge for on-line breath analysis. It is also important for gauging the analytical performance, accuracy, reproducibility, reliability, and stability of the measuring technology. Short-chain fatty acids (SCFAs) are of high interest for nutrition and health. Their quantification enables a deep mechanistic understanding of a wide range of biological processes and metabolic pathways, while their high volatility makes them an attractive target for breath analysis. This article reports, for the first time, the development and testing of a modular, dynamic vapor generator for the qualitative and quantitative analysis of volatile SCFAs in the gaseous phase using a secondary electrospray ionization (SESI) source coupled to a high-resolution mass spectrometer. Representative compounds tested included acetic acid, propionic acid, butyric acid, pentanoic acid and hexanoic acid. Gas-phase experiments were performed both in dry and humid (95% relative humidity) conditions from ppt to low ppb concentrations. The results obtained exhibited excellent linearity within the examined concentration range, low limits of detection and quantification down to the lower ppt area. Mixture effects were also investigated and are presented.

Digital Object Identifier (DOI): https://doi.org/10.1039/d2ay01778d
Publikations-ID (Webcode): 52038 Per E-Mail versenden

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Analysis of volatile short-chain fatty acids in the gas phase using secondary electrospray ionization high-resolution mass spectrometry.