Agroscope researchers' publications can be found in the Institutional Repository. If the PDF of the publication is freely available, it can be downloaded. Otherwise, the publication reference will inform you of where the paper was published.
By entering the Web Code a Publication can be accessed directly.
The Web Code for Agroscope publications is displayed at the bottom of the 'details' page of a publication: Publication ID (Web Code): 12345
You can search the metadata of a publication by entering a search term: Title, Subtitle, Summary, Source Name, ISBN, ISSN, DOI, Keywords
Albechaalany J., Loncke C., Driesen C., Schmidely P., Ortigues-Marty I., Zennegg M., Sauvant D., Lerch S.
Effects of breed, growth rate and dietary lipid concentration on lipophilic contaminant accumulation into growing cattle: Insight from a physiologically-based toxicokinetic model.
Ruminants occasionally face contamination incidents of persistent organic pollutant (POP; e.g., dioxins/furans) with economic and social damages (Driesen et al., 2022). Understanding the fate (absorption, distribution, metabolism, and excretion, ADME) of POPs at the animal level is key to ensure the safety of livestock systems. The rate of feed-meat transfer of POPs depends on animal physiology and feeding, as well as on contaminant physicochemical properties (Driesen et al., 2022). The objective was to explore this complex animal×diet×contaminant interaction using a mechanistic model and evaluate the effects of breed, growing rate, dietary lipid concentration and contaminant lipophilicity on feed-to-meat accumulation kinetics. The growing cattle PBTK model is promising to address the effects of different livestock systems on ADME and explore the complex ani- mal*diet*contaminant interplay. Ongoing developments include the assessment of the model predictive capabilities to deliver a practical tool for risk assessors and managers, and ultimately contribute to beef meat chemical safety.
